The genome-wide association studies have been stared as one of the most advanced biomedical discovery methods, and ever-since widely applied for the better understanding of genetic components of various diseases including diabetes. A major limitation of these studies consists in the difficulty to explain the correlation between non coding SNP-s (Single Nucleotide Polymorphisms) and the diseases investigated. Hepatocyte nuclear factor-1 alpha and beta, and -4 (HNF1A, HNF1B, HNF4) mutations have been discovered to be the cause of monogenic diabetes, especially in maturity-onset diabetes of the young (MODY). However little is known about the presence of this disease in association with different motifs of HNF- binding sites. Our aim is to investigate this question on a genomic scale and identify the degree of correlation between HNF binding site variants with MODY. The raw ChIP-seq data of published studies was selected from 5 different sequence repository sites and filtered through a set of curration criteria before being processed by our analysis pipeline (Endre Barta 13-17. EMBnet. Journal, 2011). Here we present the binding sites in the investigated tissues and the identified SNP-s in the HNF binding sites. Further laboratory experiments are needed for the validation of the differential binding sites and the impact of the SNP-s on the binding of HNF proteins to their targets.